Article
High incidence of intrahepatic cholangiocarcinoma in end-stage renal disease patients in Taiwan: analysis of a nationwide database with molecular insight of aristolochic acid exposure.
Virchows Archiv : an international journal of pathology - 1 Mar 2026
Huang Shih-Chiang, Chang Ian Yi-Feng, Wu Li-Ching, Hung Meng-Yun, Chuang Huei-Chieh, Ho Chung-Han, Chen Tse-Ching, Chiu Chia-Chun, Chen Chien-Cheng, Chen Kuang-Hua, Yeh Ta-Sen, Hsu Jun-Te, Ng Kwai-Fong, Li Chien-Feng
Abstract excerpt
Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer. Its association with chronic kidney disease (CKD) and end-stage renal disease (ESRD) is unclear. Using Taiwan's National Health Insurance Research Database (NHIRD), we analyzed the relationship between iCCA and CKD/ESRD. Molecular alterations were explored through whole-exome sequencing (WES) and Archer FusionPlex in 24...
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