Article
Aristolochic Acid in the Etiology of Renal Cell Carcinoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2016
Hoang Margaret L, Chen Chung-Hsin, Chen Pau-Chung, Roberts Nicholas J, Dickman Kathleen G, Yun Byeong Hwa, Turesky Robert J, Pu Yeong-Shiau, Vogelstein Bert, Papadopoulos Nickolas, Grollman Arthur P, Kinzler Kenneth W, Rosenquist Thomas A
Abstract excerpt
BACKGROUND: Aristolochia species used in the practice of traditional herbal medicine contains aristolochic acid (AA), an established human carcinogen contributing to urothelial carcinomas of the upper urinary tract. AA binds covalently to genomic DNA, forming aristolactam (AL)-DNA adducts. Here we investigated whether AA is also an etiologic factor in clear cell renal cell carcinoma (ccRCC). METHODS: We conducted...
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