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Article

Whole-exome sequencing reveals genomic landscape of intrahepatic cholangiocarcinoma and identifies SAV1 as a potential driver.

Nature communications - 17 Nov 2024

Zhou Zheng-Jun, Ye Yu-Hang, Hu Zhi-Qiang, Hou Yue-Ru, Liu Kai-Xuan, Sun Rong-Qi, Wang Peng-Cheng, Luo Chu-Bin, Li Jia, Zou Ji-Xue, Zhou Jian, Fan Jia, Song Cheng-Li, Zhou Shao-Lai

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma, with poor prognosis and limited treatment options. The genomic features of ICC in Chinese patients remain largely unknown. In this study, we perform deep whole-exome sequencing of 204 Chinese primary ICCs and characterize genomic alterations and clonal evolution, and reveal their associations...

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Identifiers

PMID: 39551842
DOI: 10.1038/s41467-024-54387-8
PMCID: PMC11570600

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