Comprehensive molecular characterization of collecting duct carcinoma for therapeutic vulnerability.

doi:10.1038/s44321-024-00102-5

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Comprehensive molecular characterization of collecting duct carcinoma for therapeutic vulnerability.

EMBO molecular medicine - 1 Sept 2024

Guan Peiyong, Chen Jianfeng, Mo Chengqiang, Fukawa Tomoya, Zhang Chao, Cai Xiuyu, Li Mei, Hong Jing Han, Chan Jason Yongsheng, Ng Cedric Chuan Young, Lee Jing Yi, Wong Suet Far, Liu Wei, Zeng Xian, Wang Peili, Xiao Rong, Rajasegaran Vikneswari, Myint Swe Swe, Lim Abner Ming Sun, Yeong Joe Poh Sheng, Tan Puay Hoon, Ong Choon Kiat, Xu Tao, Du Yiqing, Bai Fan, Yao Xin, Teh Bin Tean, Tan Jing

Abstract excerpt

Collecting duct carcinoma (CDC) is an aggressive rare subtype of kidney cancer with unmet clinical needs. Little is known about its underlying molecular alterations and etiology, primarily due to its rarity, and lack of preclinical models. This study aims to comprehensively characterize molecular alterations in CDC and identify its therapeutic vulnerabilities. Through whole-exome and transcriptome sequencing, we...

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Identifiers

PMID: 39122888
DOI: 10.1038/s44321-024-00102-5
PMCID: PMC11393068

Genes

CDK9
KRAS
NF2
TP53

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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