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Article

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting.

Nature communications - 12 Oct 2016

Wrobel Eva, Rothenberg Ina, Krisp Christoph, Hundt Franziska, Fraenzel Benjamin, Eckey Karina, Linders Joannes T M, Gallacher David J, Towart Rob, Pott Lutz, Pusch Michael, Yang Tao, Roden Dan M, Kurata Harley T, Schulze-Bahr Eric, Strutz-Seebohm Nathalie, Wolters Dirk, Seebohm Guiscard

Abstract excerpt

Most small-molecule inhibitors of voltage-gated ion channels display poor subtype specificity because they bind to highly conserved residues located in the channel's central cavity. Using a combined approach of scanning mutagenesis, electrophysiology, chemical ligand modification, chemical cross-linking, MS/MS-analyses and molecular modelling, we provide evidence for the binding site for adamantane derivatives...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27731317
DOI: 10.1038/ncomms12795
PMCID: PMC5064022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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