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Article

KMT2A is a prerequisite of malignant transformation during IDH-mutant gliomagenesis.

Neuro-oncology - 1 Jun 2026

Koch Marilin S, Deo Minh, Schmidt Claudia, Podolak Adrianna, Taranda Julian, Hoetker Michael S, Turcan Șevin

Abstract excerpt

BACKGROUND: IDH1R132H is the defining mutation of low-grade gliomas (LGGs), driving broad epigenetic rewiring that leads to malignant transformation. Recent studies have demonstrated that cell fate change from astrocyte to LGG is accompanied by redistribution of H3K4 methylation. By modulating the H3K4 methyltransferase KMT2A in a conditionally IDH1R132H-expressing human astrocyte model system, we sought to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41537229
DOI: 10.1093/neuonc/noag006
PMCID: PMC13231173

Genes

KMT2A
L1CAM
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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