Article
A patient-derived cell model for malignant transformation in IDH-mutant glioma.
Acta neuropathologica communications - 10 Sept 2024
Kim Olga, Sergi Zach, Yu Guangyang, Yamamoto Kazutoshi, Quezado Martha, Abdullaev Zied, Crooks Danel R, Kishimoto Shun, Li Qi, Lu Peng, Blackman Burchelle, Andresson Thorkell, Wu Xiaolin, Tran Bao, Wei Jun S, Zhang Wei, Zhang Meili, Song Hua, Khan Javed, Krishna Murali C, Brender Jeffrey R, Wu Jing
Abstract excerpt
Malignant transformation (MT) is commonly seen in IDH-mutant gliomas. There has been a growing research interest in revealing its underlying mechanisms and intervening prior to MT at the early stages of the transforming process. Here we established a unique pair of matched 3D cell models: 403L, derived from a low-grade glioma (LGG), and 403H, derived from a high-grade glioma (HGG), by utilizing IDH-mutant...
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