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Article

Mutant IDH Modulates Suppressive Myeloid Populations in Malignant Glioma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 13 Sept 2024

Grewal Eric P, Richardson Leland G K, Sun Jing, Ramapriyan Rishab, Martinez-Lage Maria, Miller Julie J, Carter Bob S, Cahill Daniel P, Curry William T, Choi Bryan D

Abstract excerpt

PURPOSE: Mutations in the isocitrate dehydrogenase (IDH) genes IDH1 and IDH2 have critical diagnostic and prognostic significance in diffuse gliomas. Neomorphic mutant IDH activity has been previously implicated in T-cell suppression; however, the effects of IDH mutations on intratumoral myeloid populations remain underexplored. In this study, we investigate the influence of IDH status on the myeloid compartment...

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Identifiers

PMID: 39042445
DOI: 10.1158/1078-0432.CCR-24-1056
PMCID: PMC11426330

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