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Article

CD39 polymorphism enables lung thrombosis in sickle cell disease.

Nature communications - 14 Jan 2026

Brzoska Tomasz, Kaminski Tomasz W, Katoch Omika, Menchikova Elizaveta V, Alagbe Adekunle E, Tashbook Sarah E, Tofovic Stevan P, Jonassaint Jude C, St Croix Claudette M, Watkins Simon C, Howe Shane, Field Joshua J, Seyerle Amanda A, Pradhan-Sundd Tirthadipa, Laurie Cecilia, Pankratz Nathan D, Smith Nicholas L, Goode Ellen L, Pankow James S, Kooperberg Charles, Kato Gregory J, Zhang Yingze, Novelli Enrico M, Gladwin Mark T, Jackson Edwin K, Nouraie Seyed M, Sundd Prithu

Abstract excerpt

Sickle cell disease (SCD) is the most common monogenic-hemolytic disorder affecting people of African ancestry. Adenosine diphosphate (ADP) released following intravascular hemolysis activates platelets by stimulating purinergic receptors to promote thrombosis. Despite brisk intravascular hemolysis, which releases high levels of ADP into plasma, and evidence of platelet and hemostatic activation, it remains...

Topics

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Adenosine Diphosphate
Anemia, Sickle Cell
Apyrase
Blood Platelets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platelet Aggregation

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Identifiers

PMID: 41530145
DOI: 10.1038/s41467-026-68396-2
PMCID: PMC12909804

Genes

SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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