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Prothrombotic mechanisms in patients with congenital p.Cys89Tyr mutation in CD59.

Thrombosis research - 1 Aug 2018

Tabib Adi, Hindi Issam, Karbian Netanel, Zelig Orly, Falach Batla, Mevorach Dror

Abstract excerpt

BACKGROUND: Thrombosis is the prognostic factor with the greatest effect on survival in patients with paroxysmal nocturnal hemoglobinuria (PNH), who lack dozens of membrane surface proteins. We recently described a primary homozygous Cys89Tyr congenital nonfunctioning CD59 in humans with clinical manifestation in infancy, associated with chronic hemolysis, recurrent strokes, and relapsing peripheral demyelinating...

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PMID: 29929138
DOI: 10.1016/j.thromres.2018.06.006

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