Article
Platelet Dysfunction and Thrombosis in JAK2V617F-Mutated Primary Myelofibrotic Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2020
Matsuura Shinobu, Thompson Cristal R, Belghasem Mostafa Elmokhtra, Bekendam Roelof H, Piasecki Andrew, Leiva Orly, Ray Anjana, Italiano Joseph, Yang Moua, Merill-Skoloff Glenn, Chitalia Vipul C, Flaumenhaft Robert, Ravid Katya
Abstract excerpt
OBJECTIVE: The risk of thrombosis in myeloproliferative neoplasms, such as primary myelofibrosis varies depending on the type of key driving mutation (JAK2 [janus kinase 2], CALR [calreticulin], and MPL [myeloproliferative leukemia protein or thrombopoietin receptor]) and the accompanying mutations in other genes. In the current study, we sought to examine the propensity for thrombosis, as well as platelet...
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