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Article

Integrated Genomic Analysis Reveals the Synergistic Role of PNPLA3 and ABCC8 Variants in Diabetic MASLD in Pakistan.

Medical sciences (Basel, Switzerland) - 5 Sept 2025

Shabbir Asma, Khatoon Ambrina, Abbas Zaigham, Srivastava Sucheta, Mirza Talat

Abstract excerpt

Introduction: Metabolic dysfunction associated steatotic liver disease (MASLD), previously termed as nonalcoholic fatty liver disease (NAFLD), is a growing global health concern, particularly in South Asia. While PNPLA3 is a well-recognized genetic contributor to MASLD, the role of other metabolic genes, such as ABCC8, remains unexplored in South Asian populations. In this study, we aim to investigate the genetic...

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Source

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Identifiers

PMID: 40981175
DOI: 10.3390/medsci13030178
PMCID: PMC12452525

Genes

ABCC8
PNPLA3
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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