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Article

PNPLA3 polymorphisms and risk of hepatic and extrahepatic outcomes in MASLD: A meta-analysis of observational studies.

JHEP reports : innovation in hepatology - 1 Aug 2026

Celsa Ciro, Pennisi Grazia, Tulone Adele, Ciancimino Giacinta, Vaccaro Marco, Pecorella Fabiana, Di Maria Gabriele, Enea Marco, Targher Giovanni, Valenti Luca, Romeo Stefano, Cammà Calogero, Petta Salvatore

Abstract excerpt

BACKGROUND & AIMS: The rs738409C>G polymorphism in the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3 I148M variant) contributes to the largest fraction of metabolic dysfunction-associated steatotic liver disease (MASLD) heritability. However, its prognostic impact on long-term clinical outcomes related to MASLD remains incompletely characterized. We performed a meta-analysis of observational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Liver Neoplasms

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Source

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Identifiers

PMID: 42250763
DOI: 10.1016/j.jhepr.2026.101918
PMCID: PMC13382268

Genes

PNPLA3
IMPACT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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PNPLA3 polymorphisms and risk of hepatic and extrahepatic outcomes in MASLD: A meta-analysis of observational studies.PMID 42250763Read ↗

Global epidemiology and implications of PNPLA3 I148M variant in MASLD: a systematic review and meta-analysisSemantic proximity Read ↗

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Global Epidemiological Impact of PNPLA3 I148M on Liver Disease.Semantic proximity Read ↗

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The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohortSemantic proximity Read ↗

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease.Semantic proximity Read ↗

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