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Article

Exploring Hepatocellular Carcinoma Pathogenesis: The Influence of Genetic Polymorphisms.

Current pharmaceutical design - 1 Jan 2025

Mollazadeh Samaneh, Saeedi Nikoo, Al-Asady Abdulridha Mohammed, Ghorbani Elnaz, Khazaei Majid, Ryzhikov Mikhail, Avan Amir, Hassanian Seyed Mahdi

Abstract excerpt

Hepatocellular carcinoma (HCC) is influenced by several factors, among which genetic polymorphisms play a key role. Polymorphisms in various genes affect key pathways involved in HCC development, including metabolism, expression of inflammatory cytokines, cell proliferation, and apoptosis regulation. These polymorphisms induce differential effects on susceptibility to HCC, disease progression, and treatment...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Hepatocellular
Liver Neoplasms
Polymorphism, Genetic
Genetic Predisposition to Disease
Animals

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Identifiers

PMID: 39297458
DOI: 10.2174/0113816128327773240827062719

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