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Association Between the PNPLA3 rs738409 Polymorphism and Susceptibility to Non-Alcoholic Fatty Liver Disease: A Systematic Review and Ethnicity-Stratified Meta-analysis

2026-06-18

Abstract excerpt

<title>Abstract</title> <p>Background Non-alcoholic fatty liver disease (NAFLD), now largely encompassed by the term metabolic dysfunction-associated steatotic liver disease (MASLD), is a major cause of chronic liver disease worldwide. The PNPLA3 rs738409 C > G variant, which encodes the I148M substitution, has been repeatedly associated with hepatic steatosis, but published estimates of its association with NAF...

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Literature Corpus work
655166ac-a684-5aa4-87fa-88e340dd3014
DOI
10.21203/rs.3.rs-9573413/v1
Open publication

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