Article
PNPLA3, Obesity, and Heavy Alcohol Use in Cirrhosis Patients May Exert a Synergistic Increase Hepatocellular Carcinoma Risk.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Sept 2024
Thrift Aaron P, Kanwal Fasiha, Lim Hyeyeun, Duong Hao, Liu Yanhong, Singal Amit G, Khaderi Saira, Asrani Sumeet K, Amos Christopher I, El-Serag Hashem B
Abstract excerpt
BACKGROUND & AIMS: In patients with cirrhosis, continued heavy alcohol consumption and obesity may increase risk of hepatocellular carcinoma (HCC). We examined whether germline susceptibility to hepatic steatosis not only independently predisposes to HCC but may also act synergistically with other risk factors. METHODS: We analyzed data from 1911 patients in 2 multicenter prospective cohort studies in the United...
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