Article
Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis.
Journal of hepatology - 1 Sept 2011
Cai Tao, Dufour Jean-François, Muellhaupt Beat, Gerlach Tilman, Heim Markus, Moradpour Darius, Cerny Andreas, Malinverni Raffaele, Kaddai Vincent, Bochud Murielle, Negro Francesco, Bochud Pierre-Yves
Abstract excerpt
BACKGROUND & AIMS: Steatosis is a prominent feature of hepatitis C, especially in patients infected with genotype 3. The analysis of genetic polymorphisms influencing steatosis in chronic hepatitis C has been limited by the studies' small sample size, and important single nucleotide polymorphisms (SNPs), such as those in the patatin-like phospholipase family 3 protein (PNPLA3), were never evaluated. METHODS: We...
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