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Article

SOX2 confers tumour permissiveness in a specific skin progenitor population.

Nature communications - 8 Jan 2026

Centeno Patricia P, Chester Christopher, Kanellos Georgios, Ford Catriona A, Cammareri Patrizia, Inman Gareth J, Jamieson Thomas, Ridgway Rachel A, Marais Richard, Campbell Andrew D, Sansom Owen J

Abstract excerpt

The continuous renewal of the skin relies on stem and progenitor cells, yet their differential susceptibility to oncogenic mutations in cutaneous squamous cell carcinoma (cSCC) remains unclear. Rapid cSCC develops in melanoma patients on BRAF inhibitors due to paradoxical MAPK activation. To model this in mice, we use two complementary approaches: HRASG12V with a BRAF inhibitor to mimic paradoxical MAPK...

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Topics

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Share to Skin
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Melanoma

Share to Neoplastic Stem Cells

Share to Skin Neoplasms

Share to SOXB1 Transcription Factors

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Source

Open in PubMed Open full text

Identifiers

PMID: 41507151
DOI: 10.1038/s41467-025-66251-4
PMCID: PMC12789432

Genes

SOX2
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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