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Article

SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

31 Mar 2014

Abstract excerpt

Melanoma is one of the most aggressive types of human cancer, characterized by enhanced heterogeneity and resistance to conventional therapy at advanced stages. We and others have previously shown that HEDGEHOG-GLI (HH-GLI) signaling is required for melanoma growth and for survival and expansion of melanoma-initiating cells (MICs). Recent reports indicate that HH-GLI signaling regulates a set of genes typically...

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PMID: 24681955
DOI: 10.1038/onc.2014.71

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