Article

SOX2 empowers a rapid tumorigenic programme from the tumour-resistant population in the skin

2025-01-26

Abstract excerpt

The skin undergoes continuous renewal, relying on stem and progenitor cells to maintain its barrier function. Over time, multiple oncogenic and tumour suppressor events accumulate. How the skin tolerates these mutations in different populations and how cutaneous squamous cell carcinoma (cSCC) emerges from mutant clones is poorly understood. Rapid cSCC development can ensue in melanoma patients treated with BRAF in...

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Literature Corpus work: 87ed6c2d-7fd4-5eb3-957a-47b68f2f0bdb
DOI: 10.1101/2025.01.23.634502

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