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Article

Defining the clonal dynamics leading to mouse skin tumour initiation.

Nature - 18 Aug 2016

Sánchez-Danés Adriana, Hannezo Edouard, Larsimont Jean-Christophe, Liagre Mélanie, Youssef Khalil Kass, Simons Benjamin D, Blanpain Cédric

Abstract excerpt

The changes in cell dynamics after oncogenic mutation that lead to the development of tumours are currently unknown. Here, using skin epidermis as a model, we assessed the effect of oncogenic hedgehog signalling in distinct cell populations and their capacity to induce basal cell carcinoma, the most frequent cancer in humans. We found that only stem cells, and not progenitors, initiated tumour formation upon...

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Identifiers

PMID: 27459053
DOI: 10.1038/nature19069
PMCID: PMC5068560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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