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Article

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.

Nature communications - 25 Aug 2016

Cammareri Patrizia, Rose Aidan M, Vincent David F, Wang Jun, Nagano Ai, Libertini Silvana, Ridgway Rachel A, Athineos Dimitris, Coates Philip J, McHugh Angela, Pourreyron Celine, Dayal Jasbani H S, Larsson Jonas, Weidlich Simone, Spender Lindsay C, Sapkota Gopal P, Purdie Karin J, Proby Charlotte M, Harwood Catherine A, Leigh Irene M, Clevers Hans, Barker Nick, Karlsson Stefan, Pritchard Catrin, Marais Richard, Chelala Claude, South Andrew P, Sansom Owen J, Inman Gareth J

Abstract excerpt

Melanoma patients treated with oncogenic BRAF inhibitors can develop cutaneous squamous cell carcinoma (cSCC) within weeks of treatment, driven by paradoxical RAS/RAF/MAPK pathway activation. Here we identify frequent TGFBR1 and TGFBR2 mutations in human vemurafenib-induced skin lesions and in sporadic cSCC. Functional analysis reveals these mutations ablate canonical TGFβ Smad signalling, which is localized to...

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Source

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Identifiers

PMID: 27558455
DOI: 10.1038/ncomms12493
PMCID: PMC5007296

Genes

BRAF
TGFBR1
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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