Article
Stem cells in melanoma development.
Cancer letters - 8 Jul 2009
Sabatino Marianna, Stroncek David F, Klein Harvey, Marincola Francesco M, Wang Ena
Abstract excerpt
Cutaneous melanoma is a significant health problem worldwide. Available treatments can induce objective tumor regression in a small percent of patients, but these responses are not always associated with improved long-term survival. The resistance of melanoma to therapy and its predestined recurrence are related to the genetic heterogeneity and genomic instability of the tumor. For many years these genetic...
Topics
- Adult Stem Cells
- Animals
- Cell Transformation, Neoplastic
- Humans
- Melanocytes
- Melanoma
- Mutation
- Neoplastic Stem Cells
- Skin Neoplasms
