Mouse-INtraDuctal (MIND): an in vivo model for studying the underlying mechanisms of DCIS malignancy.

doi:10.1002/path.5820

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Article

Mouse-INtraDuctal (MIND): an in vivo model for studying the underlying mechanisms of DCIS malignancy.

The Journal of pathology - 1 Feb 2022

Hong Yan, Limback Darlene, Elsarraj Hanan S, Harper Haleigh, Haines Haley, Hansford Hayley, Ricci Michael, Kaufman Carolyn, Wedlock Emily, Xu Mingchu, Zhang Jianhua, May Lisa, Cusick Therese, Inciardi Marc, Redick Mark, Gatewood Jason, Winblad Onalisa, Aripoli Allison, Huppe Ashley, Balanoff Christa, Wagner Jamie L, Amin Amanda L, Larson Kelsey E, Ricci Lawrence, Tawfik Ossama, Razek Hana, Meierotto Ruby O, Madan Rashna, Godwin Andrew K, Thompson Jeffrey, Hilsenbeck Susan G, Futreal Andy, Thompson Alastair, Hwang E Shelley, Fan Fang, Behbod Fariba

Abstract excerpt

Due to widespread adoption of screening mammography, there has been a significant increase in new diagnoses of ductal carcinoma in situ (DCIS). However, DCIS prognosis remains unclear. To address this gap, we developed an in vivo model, Mouse-INtraDuctal (MIND), in which patient-derived DCIS epithelial cells are injected intraductally and allowed to progress naturally in mice. Similar to human DCIS, the cancer...

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Identifiers

PMID: 34714554
DOI: 10.1002/path.5820
PMCID: PMC8738143

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