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Article

Targeted gene sequencing and transcriptome sequencing reveal characteristics of NUP98 rearrangement in pediatric acute myeloid leukemia.

European journal of medical research - 2 Sept 2024

Zhang Jing-Ying, Chen Chun-Rong, Qin Jia-Yue, Shen Di-Ying, Liu Li-Xia, Song Hua, Xia Tian, Xu Wei-Qun, Wang Yan, Zhu Feng, Fang Mei-Xin, Shen He-Ping, Liao Chan, Dong Ao, Cao Shan-Bo, Tang Yong-Min, Xu Xiao-Jun

Abstract excerpt

BACKGROUND: NUP98 rearrangements (NUP98-r) are rare but overrepresented mutations in pediatric acute myeloid leukemia (AML) patients. NUP98-r is often associated with chemotherapy resistance and a particularly poor prognosis. Therefore, characterizing pediatric AML with NUP98-r to identify aberrations is critically important. METHODS: Here, we retrospectively analyzed the clinicopathological features, genomic and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39223643
DOI: 10.1186/s40001-024-02042-9
PMCID: PMC11370121

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