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Article

Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss.

Comprehensive Physiology - 1 Feb 2026

Suryadevara Vidyani, Krehbial Connor J, Valiya Anuradha K, Vang Melinda, Balanta-Melo Julian, Eleniste Pierre P, Posritong Sumana, Hong Jung Min, Chester Katie, Pagnotti Gabriel M, Bellido Teresita, Willis Monte S, Bruzzaniti Angela

Abstract excerpt

Accelerated bone loss has been reported in the early stages of Alzheimer's disease (AD) as indicated by reduced bone mineral density and increased fracture risk in these patients, compared to healthy individuals. In the present study, we investigated bone loss in mouse models of familial Alzheimer's disease harboring the Presenilin 1 (L166P) knock-in mutation (PSEN1 KI), with or without the human amyloid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41496612
DOI: 10.1002/cph4.70097
PMCID: PMC12775720

Genes

PSEN1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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