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Article

Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence.

Communications biology - 25 Nov 2021

Pan Jin-Xiu, Sun Dong, Lee Daehoon, Xiong Lei, Ren Xiao, Guo Hao-Han, Yao Ling-Ling, Lu Yuyi, Jung Caroline, Xiong Wen-Cheng

Abstract excerpt

Patients with Alzheimer's disease (AD) often have osteoporosis or osteopenia. However, their direct link and relationship remain largely unclear. Previous studies have detected osteoporotic deficits in young adult Tg2576 and TgAPPsweOCN mice, which express APPswe (Swedish mutant) ubiquitously and selectively in osteoblast (OB)-lineage cells. This raises the question, whether osteoblastic APPswe contributes to AD...

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Identifiers

PMID: 34824365
DOI: 10.1038/s42003-021-02843-2
PMCID: PMC8617160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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