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Article

Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages.

Neuroscience - 29 Oct 2015

Devi L, Ohno M

Abstract excerpt

β-Site APP-cleaving enzyme 1 (BACE1) initiates the generation of amyloid-β (Aβ), thus representing a prime therapeutic target for Alzheimer's disease (AD). Previous work including ours has used BACE1 haploinsufficiency (BACE1(+/-); i.e., 50% reduction) as a therapeutic relevant model to evaluate the efficacy of partial β-secretase inhibition. However, it is unclear whether the extent of Aβ reductions in amyloid...

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Identifiers

PMID: 26314636
DOI: 10.1016/j.neuroscience.2015.08.037
PMCID: PMC4591236

Genes

BACE1
APP

Provenance

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