Article
The Ames dwarf mutation attenuates Alzheimer's disease phenotype of APP/PS1 mice.
Neurobiology of aging - 1 Apr 2016
Puig Kendra L, Kulas Joshua A, Franklin Whitney, Rakoczy Sharlene G, Taglialatela Giulio, Brown-Borg Holly M, Combs Colin K
Abstract excerpt
APP/PS1 double transgenic mice expressing human mutant amyloid precursor protein (APP) and presenilin-1 (PS1) demonstrate robust brain amyloid beta (Aβ) peptide containing plaque deposition, increased markers of oxidative stress, behavioral dysfunction, and proinflammatory gliosis. On the other h...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Brain
- Cells, Cultured
- Cytokines
- Gene Expression
- Gliosis
- Growth Hormone
- Homeodomain Proteins
- Insulin-Like Growth Factor I
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Phenotype
- Plaque, Amyloid
- Presenilin-1
- Prolactin