Article
The Ames dwarf mutation attenuates Alzheimer's disease phenotype of APP/PS1 mice.
Neurobiology of aging - 1 Apr 2016
Puig Kendra L, Kulas Joshua A, Franklin Whitney, Rakoczy Sharlene G, Taglialatela Giulio, Brown-Borg Holly M, Combs Colin K
Abstract excerpt
APP/PS1 double transgenic mice expressing human mutant amyloid precursor protein (APP) and presenilin-1 (PS1) demonstrate robust brain amyloid beta (Aβ) peptide containing plaque deposition, increased markers of oxidative stress, behavioral dysfunction, and proinflammatory gliosis. On the other hand, lack of growth hormone, prolactin, and thyroid-stimulating hormone due to a recessive mutation in the Prop 1 gene...
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