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Article

Gene deletion of Pregnancy-associated Plasma Protein-A (PAPP-A) improves pathology and cognition in an Alzheimer's disease mouse model

28 Sept 2024

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disease of age with no effective preventative or treatment approaches. Deeper understanding of the mechanisms underlying the accumulation of toxic β-amyloid oligopeptides and the formation of amyloid plaque in AD has the potential to identify new therapeutic targets. Prior research links the insulin-like growth factor (IGF) system to pathologic...

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Identifiers

PMID: 39349117
DOI: 10.1016/j.expneurol.2024.114976

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Research trail→

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Gene deletion of Pregnancy-associated Plasma Protein-A (PAPP-A) improves pathology and cognition in an Alzheimer's disease mouse modelPMID 39349117Read ↗

PAPP-A: a promising therapeutic target for healthy longevitySemantic proximity Read ↗

Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice.Semantic proximity Read ↗

Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development.Semantic proximity Read ↗

Inhibition of longevity regulator PAPP‐A modulates tissue homeostasis via restraint of mesenchymal stromal cellsSemantic proximity Read ↗

Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet.Semantic proximity Read ↗

Pharmacological inhibition of longevity regulator PAPP-A restrains mesenchymal stromal cell activitySemantic proximity Read ↗

Low IGF-I Bioavailability Impairs Growth and Glucose Metabolism in a Mouse Model of Human PAPPA2 p.Ala1033Val MutationSemantic proximity Read ↗

Loss of pregnancy‐associated plasma protein A extends lifespan in miceSemantic proximity Read ↗

Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes.Semantic proximity Read ↗

Role of the Insulin-like Growth Factor System in Neurodegenerative DiseaseSemantic proximity Read ↗

Brain-specific PAPP-A knock-out mice?Semantic proximity Read ↗

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