Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice.

Endocrinology - 1 Jun 2012

Drummond Eleanor S, Martins Ralph N, Handelsman David J, Harvey Alan R

Abstract excerpt

Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal (hpg) male and female mice. hpg Mice have a spontaneous, inactivating genetic mutation in the GnRH gene resulting in life-long deficiency of gonadotropins and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gonadotropin-Releasing Hormone

Share to Gonadotropins

Share to Hippocampus

Share to Interleukin-1beta

Share to Mice, Inbred C3H

Share to Presenilin-1

Source

Identifiers

PMID: 22514046
DOI: 10.1210/en.2011-2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice.PMID 22514046Read ↗

Genetic Ablation of Luteinizing Hormone Receptor Improves the Amyloid Pathology in a Mouse Model of Alzheimer DiseaseSemantic proximity Read ↗

Transcriptional Dysregulation in the Hippocampus of a murine model for Parkinson’s Disease Cognition Impairment is Driven by Sex, Age, and Alpha-synuclein overexpressionSemantic proximity Read ↗

Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease.Semantic proximity Read ↗

Targeting the hypothalamus for modeling age-related DNA methylation and developing OXT-GnRH combinational therapy against Alzheimer’s disease-like pathologies in male mouse modelSemantic proximity Read ↗

Role of sex and high fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Perimenopause promotes neuroinflammation in select hippocampal regions in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss.Semantic proximity Read ↗

Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice.Semantic proximity Read ↗

Gene–Dose–Dependent Reduction <i>Fshr</i> Expression Improves Spatial Memory Deficits in Alzheimer’s MiceSemantic proximity Read ↗

Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivitySemantic proximity Read ↗

Gender- and Age-Dependent γ-Secretase Activity in Mouse Brain and Its Implication in Sporadic Alzheimer DiseaseSemantic proximity Read ↗

The LH receptor regulates hippocampal spatial memory and restores dendritic spine density in ovariectomized APP/PS1 AD miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.