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Article

Mapping the Genomic Limits of De-Extinction in the Face of Ancient DNA Degradation.

Genome biology and evolution - 2 Jan 2026

Lin Jianqing, Long Xinrui, Gao Yan, Liu Wenhua, Gilbert M Thomas P

Abstract excerpt

The de-extinction of species using genome-editing approaches depends on acquiring high-quality genomic information from the extinct target. However, the degraded nature of the ancient DNA (aDNA) that is typical for most extinct species, poses significant challenges to achieving comprehensive genome reconstruction. A systematic evaluation of the minimum sequencing effort that is required to reliably map the genome...

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Identifiers

PMID: 41482712
DOI: 10.1093/gbe/evaf251
PMCID: PMC12794020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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