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Article

Inferring Heterozygosity from Ancient and Low Coverage Genomes.

Genetics - 1 Jan 2017

Kousathanas Athanasios, Leuenberger Christoph, Link Vivian, Sell Christian, Burger Joachim, Wegmann Daniel

Abstract excerpt

While genetic diversity can be quantified accurately from high coverage sequencing data, it is often desirable to obtain such estimates from data with low coverage, either to save costs or because of low DNA quality, as is observed for ancient samples. Here, we introduce a method to accurately infer heterozygosity probabilistically from sequences with average coverage [Formula: see text] of a single individual....

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Identifiers

PMID: 27821432
DOI: 10.1534/genetics.116.189985
PMCID: PMC5223511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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