Impacts of low coverage depths and post-mortem DNA damage on variant calling: a simulation study.

doi:10.1186/s12864-015-1219-8

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Impacts of low coverage depths and post-mortem DNA damage on variant calling: a simulation study.

BMC genomics - 23 Jan 2015

Parks Matthew, Lambert David

Abstract excerpt

BACKGROUND: Massively parallel sequencing platforms, featuring high throughput and relatively short read lengths, are well suited to ancient DNA (aDNA) studies. Variant identification from short-read alignment could be hindered, however, by low DNA concentrations common to historic samples, which constrain sequencing depths, and post-mortem DNA damage patterns. RESULTS: We simulated pairs of sequences to act as...

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Impacts of low coverage depths and post-mortem DNA damage on variant calling: a simulation study.

Abstract excerpt

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Impacts of low coverage depths and post-mortem DNA damage on variant calling: a simulation study.

Abstract excerpt

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