Article

Pre-processing of paleogenomes: Mitigating reference bias and postmortem damage in ancient genome data

2023-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Ancient DNA analysis is subject to various technical challenges, including bias towards the reference allele (“reference bias”), postmortem damage (PMD) that confounds real variants, and limited coverage. Here, we conduct a systematic comparison of alternative approaches against reference bias and against PMD. To reduce reference bias, we either (a) mask variable sites before alignment or (b) al...

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Literature Corpus work: 73a6d047-d383-5e13-9f5a-689c35bb8b44
DOI: 10.1101/2023.11.11.566695

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Pre-processing of paleogenomes: Mitigating reference bias and postmortem damage in ancient genome dataDOI 10.1101/2023.11.11.566695Read

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