Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational challenges in the analysis of ancient DNA.

Genome biology - 1 Jan 2010

Prüfer Kay, Stenzel Udo, Hofreiter Michael, Pääbo Svante, Kelso Janet, Green Richard E

Abstract excerpt

High-throughput sequencing technologies have opened up a new avenue for studying extinct organisms. Here we identify and quantify biases introduced by particular characteristics of ancient DNA samples. These analyses demonstrate the importance of closely related genomic sequence for correctly identifying and classifying bona fide endogenous DNA fragments. We show that more accurate genome divergence estimates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Computational Biology
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Nucleic Acid

Share to Extinction, Biological

Share to Sequence Alignment

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 20441577
DOI: 10.1186/gb-2010-11-5-r47
PMCID: PMC2898072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational challenges in the analysis of ancient DNA.PMID 20441577Read ↗

Assessing the Relationship of Ancient and Modern Populations.Semantic proximity Read ↗

New developments in ancient genomics.Semantic proximity Read ↗

BADGER: evaluating the performance of ancient DNA genetic relatedness estimation methods using high-fidelity pedigree simulationsSemantic proximity Read ↗

Inferring Heterozygosity from Ancient and Low Coverage Genomes.Semantic proximity Read ↗

Joint estimation of relatedness coefficients and allele frequencies from ancient samplesSemantic proximity Read ↗

Inferring heterozygosity from ancient and low coverage genomesSemantic proximity Read ↗

Joint Estimation of Relatedness Coefficients and Allele Frequencies from Ancient Samples.Semantic proximity Read ↗

Competitive mapping allows to identify and exclude human DNA contamination in ancient faunal genomic datasetsSemantic proximity Read ↗

Improving data archiving practices in ancient genomicsSemantic proximity Read ↗

Evaluating the performance of ancient DNA genetic relatedness estimation methods using high-fidelity pedigree simulations.Semantic proximity Read ↗

BREADR: An R Package for the Bayesian Estimation of Genetic Relatedness from Low-coverage Genotype DataSemantic proximity Read ↗

A curated dataset of modern and ancient high-coverage shotgun human genomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.