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Article

Improving ancient DNA read mapping against modern reference genomes.

BMC genomics - 10 May 2012

Schubert Mikkel, Ginolhac Aurelien, Lindgreen Stinus, Thompson John F, Al-Rasheid Khaled A S, Willerslev Eske, Krogh Anders, Orlando Ludovic

Abstract excerpt

BACKGROUND: Next-Generation Sequencing has revolutionized our approach to ancient DNA (aDNA) research, by providing complete genomic sequences of ancient individuals and extinct species. However, the recovery of genetic material from long-dead organisms is still complicated by a number of issues, including post-mortem DNA damage and high levels of environmental contamination. Together with error profiles specific...

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PMID: 22574660
DOI: 10.1186/1471-2164-13-178
PMCID: PMC3468387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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