Article

Inferring heterozygosity from ancient and low coverage genomes

2016-04-01

Abstract excerpt

<h4>ABSTRACT</h4> While genetic diversity can be quantified accurately from high coverage sequencing, it is often desirable to obtain such estimates from low coverage data, either to save costs or because of low DNA quality as observed for ancient samples. Here we introduce a method to accurately infer heterozygosity probabilistically from very low coverage sequences of a single individual. The method relaxes the...

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Literature Corpus work: 3a962807-a618-5a4a-9feb-15016c22f124
DOI: 10.1101/046748

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