Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synergistic intragenic epigenetic deregulation by IDH2 and SRSF2 mutations causes mis-splicing of key transcriptional regulators.

Science advances - 2 Jan 2026

Telonis Aristeidis G, Stanley Robert F, Adelman Emmalee R, Yoshimi Akihide, Adele Adedamola A, Cruz Angelique, Wiseman Daniel H, Abdel-Wahab Omar, Figueroa Maria E

Abstract excerpt

Genes affecting DNA methylation (DNAme) are frequently comutated with splicing factors in acute myeloid leukemia (AML) and associate with more aggressive phenotypes. To elucidate the underlying molecular mechanisms, we deeply profiled wild-type and IDH2R140Q/SRSF2P95 single- or double-mutant AMLs. We find a unique set of mis-spliced genes and differentially methylated CpGs in double mutants. Mis-spliced exons are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Leukemic

Share to Isocitrate Dehydrogenase

Share to Leukemia, Myeloid, Acute

Share to RNA Splicing

Share to Serine-Arginine Splicing Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 41481703
DOI: 10.1126/sciadv.adu8292
PMCID: PMC12758512

Genes

IDH2
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synergistic intragenic epigenetic deregulation by IDH2 and SRSF2 mutations causes mis-splicing of key transcriptional regulators.PMID 41481703Read ↗

[Aberrant RNA splicing and development of hematological malignancies].Semantic proximity Read ↗

SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells.Semantic proximity Read ↗

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.Semantic proximity Read ↗

Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers.Semantic proximity Read ↗

The genomic landscape of core-binding factor acute myeloid leukemias.Semantic proximity Read ↗

<i>U2AF1</i> mutations alter splice site recognition in hematological malignanciesSemantic proximity Read ↗

Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells.Semantic proximity Read ↗

U2AF1 mutations alter splice site recognition in hematological malignancies.Semantic proximity Read ↗

Targeting <i>EZH2</i> Oncogenic Splicing: Decoding the Regulatory Network and Antisense CorrectionSemantic proximity Read ↗

Mir142 loss unlocks IDH2R140-dependent leukemogenesis through antagonistic regulation of HOX genes.Semantic proximity Read ↗

Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapseSemantic proximity Read ↗

DNA Methylation Signature for EZH2 Functionally Classifies Sequence Variants in Three PRC2 Complex Genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.