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Article

Mir142 loss unlocks IDH2R140-dependent leukemogenesis through antagonistic regulation of HOX genes.

Scientific reports - 10 Nov 2020

Marshall A, Kasturiarachchi J, Datta P, Guo Y, Deltcheva E, James C, Brown J, May G, Anandagoda N, Jackson I, Howard J K, Ghazaly E, Brooks S, Khwaja A, Araki M, Araki K, Linch D, Lord G M, Enver T, Nimmo R

Abstract excerpt

AML is a genetically heterogeneous disease and understanding how different co-occurring mutations cooperate to drive leukemogenesis will be crucial for improving diagnostic and therapeutic options for patients. MIR142 mutations have been recurrently detected in IDH-mutated AML samples. Here, we have used a mouse model to investigate the interaction between these two mutations and demonstrate a striking synergy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33173219
DOI: 10.1038/s41598-020-76218-8
PMCID: PMC7656267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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