Article
The genomic landscape of core-binding factor acute myeloid leukemias.
Nature genetics - 1 Dec 2016
Faber Zachary J, Chen Xiang, Gedman Amanda Larson, Boggs Kristy, Cheng Jinjun, Ma Jing, Radtke Ina, Chao Jyh-Rong, Walsh Michael P, Song Guangchun, Andersson Anna K, Dang Jinjun, Dong Li, Liu Yu, Huether Robert, Cai Zhongling, Mulder Heather, Wu Gang, Edmonson Michael, Rusch Michael, Qu Chunxu, Li Yongjin, Vadodaria Bhavin, Wang Jianmin, Hedlund Erin, Cao Xueyuan, Yergeau Donald, Nakitandwe Joy, Pounds Stanley B, Shurtleff Sheila, Fulton Robert S, Fulton Lucinda L, Easton John, Parganas Evan, Pui Ching-Hon, Rubnitz Jeffrey E, Ding Li, Mardis Elaine R, Wilson Richard K, Gruber Tanja A, Mullighan Charles G, Schlenk Richard F, Paschka Peter, Döhner Konstanze, Döhner Hartmut, Bullinger Lars, Zhang Jinghui, Klco Jeffery M, Downing James R
Abstract excerpt
Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently defined by recurrent cytogenetic abnormalities, including rearrangements involving the core-binding factor (CBF) transcriptional complex. To better understand the genomic landscape of CBF-AMLs, we analyzed both pediatric (n = 87) and adult (n = 78) samples, including cases with RUNX1-RUNX1T1 (n = 85) or CBFB-MYH11 (n = 80)...
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