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Article

[Aberrant RNA splicing and development of hematological malignancies].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2020

Yoshimi Akihide

Abstract excerpt

Dysregulation of pre-mRNA splicing and transcription is a key step in gene expression control in patients with leukemia. Herein, we discuss the occurrence of frequent overlap of mutations affecting epigenetic regulation and pre-mRNA splicing in patients with leukemia, which together promote leukemogenesis through coordinated effects on the epigenome and pre-mRNA splicing. In particular, we have determined an...

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Identifiers

PMID: 32624537
DOI: 10.11406/rinketsu.61.634

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