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Article

Identification of potential therapeutic targets for nonischemic cardiomyopathy in European ancestry: an integrated multiomics analysis.

Cardiovascular diabetology - 12 Sept 2024

Shi Kaijia, Chen Xu, Zhao Yangyang, Li Peihu, Chai Jinxuan, Qiu Jianmin, Shen Zhihua, Guo Junli, Jie Wei

Abstract excerpt

BACKGROUND: Nonischemic cardiomyopathy (NISCM) is a clinical challenge with limited therapeutic targets. This study aims to identify promising drug targets for NISCM. METHODS: We utilized cis-pQTLs from the deCODE study, which includes data from 35,559 Icelanders, and SNPs from the FinnGen study, which includes data from 1,754 NISCM cases and 340,815 controls of Finnish ancestry. Mendelian randomization (MR)...

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Identifiers

PMID: 39267096
DOI: 10.1186/s12933-024-02431-8
PMCID: PMC11396958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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