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Article

Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

1 Aug 2022

Abstract excerpt

The molecular repertoire promoting cancer cell plasticity is not fully elucidated. Here, we propose that glycosphingolipids (GSLs), specifically the globo and ganglio series, correlate and promote the transition between epithelial and mesenchymal cells. The epithelial character of ovarian cancer remains stable throughout disease progression, and spatial glycosphingolipidomics reveals elevated globosides in the...

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PMID: 35977490
DOI: 10.1016/j.celrep.2022.111181

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