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Article

POLE exonuclease domain mutations in endometrial carcinoma: a case report.

Pathologica - 1 May 2023

Pasciuto Maria Paola, Felicioni Lara, Zampacorta Claudia, Ferro Benedetta, Di Marino Pietro, Primavera Francesca Chiara, Lucidi Alessandro, Rossetti Rebecca, Barbareschi Mattia, Marchetti Antonio, Buttitta Fiamma, D'Angelo Emanuela

Abstract excerpt

Endometrial carcinoma (EC) harboring POLE exonuclease domain mutations occurs in 5-15% of ECs and frequently affects young women with low body mass index (BMI). It presents at early stage as high grade endometrioid histotype with intense tumor infiltrating lymphocytes and has good clinical outcomes and favorable prognosis. In this article we report the case of a 32-year-old woman with endometriod EC (EEC)...

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Share to Carcinoma, Endometrioid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37216304
DOI: 10.32074/1591-951X-872
PMCID: PMC10462992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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POLE exonuclease domain mutations in endometrial carcinoma: a case report.PMID 37216304Read ↗

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Interpretation of somatic POLE mutations in endometrial carcinoma.Semantic proximity Read ↗

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Endometrial Carcinomas with a "Serous" Component in Young Women Are Enriched for DNA Mismatch Repair Deficiency, Lynch Syndrome, and POLE Exonuclease Domain Mutations.Semantic proximity Read ↗

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