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Article

The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus.

Structure (London, England : 1993) - 1 Jul 2008

Stouffer Amanda L, Ma Chunlong, Cristian Lidia, Ohigashi Yuki, Lamb Robert A, Lear James D, Pinto Lawrence H, DeGrado William F

Abstract excerpt

We explore the interplay between amino acid sequence, thermodynamic stability, and functional fitness in the M2 proton channel of influenza A virus. Electrophysiological measurements show that drug-resistant mutations have minimal effects on M2's specific activity, and suggest that resistance is...

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Identifiers

PMID: 18611380
DOI: 10.1016/j.str.2008.04.011
PMCID: PMC2594009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-18611380-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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