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Article

Sporadic Multiple Gastrointestinal Stromal Tumors With Distinct KIT and PDGFRA Mutations in Two Separate Tumors: A Case Report and Literature Review.

International journal of surgical pathology - 1 Jun 2026

Akincioglu Egemen, Ciftci Elif Yagmur, Kivrak Hale, Bozlar Ugur, Bozdogan Onder

Abstract excerpt

Gastrointestinal stromal tumor accounts for approximately 80% of mesenchymal tumors and 1% to 3% of all gastrointestinal system malignancies. KIT or PDGFRA mutations are identified in approximately 92-93% of gastrointestinal stromal tumors. Both KIT and PDGFRA mutations are associated with tyrosine kinase receptor signaling pathways and are considered mutually exclusive. Herein, we report a patient with sporadic...

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Source

Identifiers

PMID: 41432662
DOI: 10.1177/10668969251404486

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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