Article
Gastrointestinal Stromal Tumor in Monozygotic Twins Shows Distinct Mutational Status: A Case Report.
The American journal of case reports - 6 Mar 2021
Sobral-Leite Marcelo, da Silva Jesse Lopes, Pimenta-Inada Haynna Kimie, Mendes Boisson Andrea Sobral, Romeiro Priscila de Almeida, Soares Parago Fernando Mallet, Valadão da Silva Marcus Vinicius M, de Melo Andreia Cristina
Abstract excerpt
BACKGROUND Gastrointestinal stromal tumors (GISTs) are rare mesenchymal cancers that affect the gastrointestinal tract and are most often located in the stomach and proximal small intestine. The most common molecular genetic abnormalities underlying GIST carcinogenesis are mutations in the tyrosine kinase gene (KIT) and in the platelet-derived growth factor receptor alpha (PDGFRA) gene. To the best of our...
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