Article
Gastrointestinal stromal tumors: molecular markers and genetic subtypes.
Hematology/oncology clinics of North America - 1 Oct 2013
Barnett Christine M, Corless Christopher L, Heinrich Michael C
Abstract excerpt
Mutation-activated signaling from the KIT and PDGFRA kinases has been successfully targeted in gastrointestinal stromal tumors (GISTs), with subtle differences between the mutations serving to refine prognosis and more precisely tailor therapy. There is a growing understanding of the molecular drivers of GISTs lacking mutations in KIT or PDGFRA, so called wild-type GISTs, further aiding in management decisions....
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