Article
Multiple sporadic gastrointestinal stromal tumors concomitant with ampullary adenocarcinoma: a case report with KIT and PDGFRA mutational analysis and miR-221/222 expression profile.
Pathology, research and practice - 1 Jun 2014
Blandamura Stella, Alessandrini Lara, Bertorelle Roberta, Simonato Francesca, Guzzardo Vincenza, Valentini Elisa, Angriman Imerio, Fassina Ambrogio
Abstract excerpt
GISTs originating multifocally at different GI sites, in patients lacking familial syndromes, could be interpreted as recurrent/metastatic disease. MiR-221/222 have recently been identified as regulators of KIT expression in GISTs. We report the first case of synchronous GISTs in the stomach and duodenum concomitant with an ampullary adenocarcinoma. Different CD117 expression patterns could be related to...
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